Breaking down Barriers to Precision Medicine

Carl is a renowned professional in the field of translational medicine and diagnostics with over 17 years of experience in drug development and technology advancement. In his previous role as the Vice President and Head of Oncology Translational Medicine at AstraZeneca Pharmaceuticals, he led a global team, spearheading biomarker strategy and translational sciences to support oncology drug development. Carl’s career also includes leadership positions at Novartis Institutes for BioMedical Research and the National Cancer Institute. He has made significant contributions to the field, with over 600 publications to his name and a reputation for mentoring future leaders in the pharmaceutical and biomedical sectors. Driven by a passion for lifelong learning and effective communication, he continues to shape the landscape of healthcare innovation. He holds a Ph.D. in Biophysical Chemistry from The Johns Hopkins University and a B.S. in Chemistry from the College of William and Mary.

Kristian is a seasoned technologist renowned for his expertise in cloud-native software engineering and computational biology. Over the course of his career, he's made significant contributions to genomics, including the development of groundbreaking methods like MuTect and platforms such as GATK and Terra. His leadership roles at the Broad Institute have seen him drive innovation, including a 1M participant whole genome variant storage solution on Google BigQuery and the launch of EUA COVID-19 diagnostic infrastructure delivering > 100,000 results per day. Kristian's extensive experience and commitment to advancing human health through technology make him a distinguished figure in the field. He holds a B.S. in Computer Science from Cornell University.

Travis is a seasoned scientist and developer with a track record of taking novel genomic technologies from conception through to clinical product launch. Travis has held key assay development roles at Ion Torrent Systems, Vanderbilt University Medical Center, Foundation Medicine, Thrive Earlier detection, and Exact Sciences. At Foundation Medicine, Travis had a key leadership role in the development and launch of their flagship circulating tumor DNA assay, taking it through different stages of commercialization and ultimately through FDA approval. At Thrive Earlier Detection, Travis focused on the development of CancerSEEK, a blood-based diagnostic test for early cancer detection and a program that was acquired by Exact Sciences. Travis completed his PhD at the University of Toronto.

Matt brings 15 years of experience in computational biology and epigenomics to Precede, and is a leader at the forefront of this dynamic field. With a Ph.D. from Duke University and a postdoc from MIT, his expertise lies in applying computational and statistical techniques to unravel the complex relationships between genetics, epigenetics, chromatin, and gene expression in human disease. For almost a decade, Matt led computational biology at Syros Pharmaceuticals, a company focused on discovering novel therapeutic targets using an advanced analysis of the disease epigenome, leading to multiple ongoing clinical trials. At MIT, Matt worked in the Kellis lab jointly between MIT computer science and the Broad Institute, where he contributed to groundbreaking epigenomic discoveries such as the characterization of chromatin state of the diversity of cell types in the human body through the NIH Epigenome Roadmap Project.

Jen is an accomplished healthcare operator, having worked across all aspects of biotech, from leading discovery research to driving commercial product launches. Most recently, Jen served as Chief Operating Officer for a stealth Flagship Series A company and as Operations Lead within her broader origination team. In her role as COO, she was responsible for successfully growing the team, setting strategic direction, leading both R&D and operations, and driving financing activities. In her capacity as Operations lead, she supported the initiation of 6 seed stage companies and was responsible for driving key facets of operational excellence across this portfolio of early-stage companies. Prior to joining Flagship, Jen was the VP of Commercial & Launch Operations for North American EMD Serono, a role that included leading delivery of four new product launches in two years, including targeted oncology medicine in lung cancer launched with a CDx. Prior to this, Jen advised healthcare clients across R&D and commercial for over eight years as a consultant at the Boston Consulting Group. Jen is passionate about diversity in science and has taken a lead role in defining and driving diversity efforts in each of her prior roles. Jen received her PhD in Biological Chemistry from MIT.

Humphrey has more than 30 years of experience leading clinical development to support innovative oncology programs and translational research at global biopharmaceutical companies and major academic institutions. He has served as Chief Medical Officer at several emerging biotechnology companies, including Harbour BioMed, Stingthera and Silicon Therapeutics; CMO in Residence at Roivant Sciences; and Chief of Medical Oncology at Evelo Biosciences, a Flagship Pioneering company. Prior to this, Humphrey held senior roles at AstraZeneca as Clinical Vice President Translational Medicine, Oncology; Novartis as Executive Director, Oncology Translational Laboratories; and Biogen. Previously, in academia, he was Assistant Professor at The Scripps Research Institute, Research Fellow at the Whitehead Institute at MIT and Clinical Fellow at Harvard Medical School, and he completed his internship at the Memorial University of Newfoundland. He is a Fellow of the College of American Pathologists and has authored nearly 100 publications. He holds a bachelor’s degree in Biochemistry and medical degree from the University of Cambridge, as well as an MS in Bioinformatics from Brandeis.

‍

Josephine brings more than a decade of corporate and business development experience supporting the development and commercialization of cancer diagnostics and genomic innovator products. Previously, Josephine was Vice President of Business Development at Exact Sciences following the acquisition of Thrive Earlier Detection, a healthcare company focused on developing a blood-based multi-cancer early detection test.

‍

Prior to Thrive, she led Business Development at 10x Genomics where she oversaw all business development activities, and implemented strategic partnerships to accelerate and strengthen 10x Genomics’ platform and application pipeline. Josephine additionally executed numerous partnerships as part of the Biopharma business development team at Foundation Medicine. She started her scientific career at the Genomics Institute of the Novartis Research Foundation and the Scripps Research Institute developing advanced genomic technologies.

‍

Josephine completed her PhD in Molecular Biology at UCLA and received her MBA with a focus on Health Care Management & Finance from the Wharton School.

Adrian is a scientist and entrepreneur with significant experience in the life sciences space. Adrian was most recently Operating Associate for the 4:59 Initiative, the venture formation arm of 5AM Ventures, and played an instrumental role in establishing Precede during its incubation. Prior to Precede, Adrian held roles at Harvard University and Vaxess Technologies where he enabled commercialization of cutting-edge technologies. His journey showcases patents, publications, and leadership roles in early-stage ventures. Adrian holds a Ph.D. in Chemical Engineering from Tufts University and also a B.S. in Chemical Engineering from Northeastern University.

Geoff is committed to advancing precision medicine through the development of high-quality and accessible CLIA-certified and FDA-approved diagnostic products across tissue and liquid biopsies. Geoff serves as Chief Product Development Officer at Precede Biosciences, where he leads a team of awesome developers. Together, he and the team have worked to develop and operationalize Precede’s proprietary wet lab platform that profiles the transcriptional biology underlying cancer and other diseases from a simple blood test. Geoff has extensive experience developing NGS-based molecular diagnostic products having played leading roles at PacBio, Foundation Medicine, Thrive Earlier detection, and Exact Sciences. Geoff completed his Ph.D at Stanford University.

Corrie is a scientist and experienced leader. She has previous experience as a biotech consultant and deputy director for Count Me In at the Broad Institute of MIT and Harvard, specializing in pioneering patient-partnered genomics research, particularly in rare cancers. She created the first decentralized national platform for generating clinically annotated genomic data sets, leading to significant changes in clinical practice for angiosarcoma patients. With numerous awards and a strong background in cancer research, Corrie is a trusted scientific advisor to several organizations and has a rich publication history in biochemistry and cancer genomics research. She obtained her Ph.D. in biochemistry from the University of Massachusetts Medical School and completed her postdoc in cancer immunology at UMass Medical School.

Kori is a dynamic leader and company builder who brings broad HR experience across biotech, pharmaceuticals, and venture capital. She previously held multiple HR leadership roles as she helped scale Relay Therapeutics from a pre-clinical startup to a publicly traded company with a broad oncology pipeline. She's recognized for her expertise in talent acquisition, leadership development, organizational design and compensation strategy. Kori previously held leadership roles at Novartis Institutes for Biomedical Research, partnering with therapeutic area executives to build high-performing teams. She serves as Head of People for 5AM Ventures’ early portfolio within its 4:59 Initiative, where she has played a pivotal role in launching multiple new companies. She holds an MBA from Northeastern University and is a professionally trained Co-Active coach.

Wendy is a business-oriented attorney who brings over twenty years of legal and intellectual property experience in biotechnology, pharmaceutical, dietary supplement, medical device and other life science-related industries. Wendy is the co-founder and managing member of TriUnity Law Group. She previously served as general counsel and senior vice president of legal and intellectual property for Synta Pharmaceuticals Corp., co-founded Microbiotix, Inc., a private pharmaceutical company focused on developing novel anti-infectives, and also held positions at Boehringer Ingelheim Pharmaceuticals, Inc. and Fish & Neave (now Ropes & Gray). She earned her J.D. from Fordham University School of Law and holds a master’s degree in organic chemistry from Columbia University and a bachelor’s degree in chemistry from Barnard College. Wendy is a registered US patent attorney and licensed to practice law in NY, CT, DC and MA.

Rehan is the founding CEO of Precede Biosciences. Prior to co-founding Precede Bio, Rehan was a member of the Healthcare Executive Committee at Merck KGaA from October 2015 to March 2021. During this time, Rehan served as the President of EMD Serono and as the Chief Marketing and Strategy officer. In these roles, Rehan was responsible for growing the global, multi-billion dollar specialty medicine franchises of oncology, neurology, immunology and infertility, which included leading and transforming the North American business, co-chairing the R&D development committee (responsible for all R&D decisions from Phase 1 to approval), leading global business development, chairing significant global R&D alliances, and having responsibility for the launches of new medicines across the major markets of the USA, the EU, China and Japan. Rehan is currently a member of the board of directors of Tyra Biosciences and the Massachusetts Biotechnology Council, and he holds a Master's degree in Molecular and Cellular Biochemistry from the University of Oxford in the U.K.